Al-Qamishli (Arabic: القامشلي‎‎, Kurdish: Qamişlo‎, Syriac: ܩܡܫܠܐ‎, translit. Qamišlo), formerly Beṯ Zālin (Syriac: ܒܝܬ ܙܐܠܝ̈ܢ‎, lit. 'House of reed'), is a city in northeastern Syria on the border with Turkey, adjoining the Turkish city of Nusaybin, and close to Iraq. According to the 2004 census, Al-Qamishli had a population of 184,231. Al-Qamishli is 680 kilometres (420 mi) northeast of Damascus.

The city is the administrative capital of the Al-Qamishli District of Al-Hasakah Governorate, and the administrative center of Nahiya al-Qamishli consisting of 92 localities with a combined population of 232,095 in 2004. In the course of the Rojava conflict, al-Qamishli became the de facto capital of the Federation of Northern Syria – Rojava.